Best Argireline Creams – July, 2020 Reviews & Product Guide

Are you considering plastic surgery or Botox to correct your wrinkles and lines? Before dropping that kind of cash for a medical procedure, which carries substantial risks in addition to being pretty pricey, consider trying a product that contains Argireline instead.

Argireline has the reputation of being an over-the-counter “Botox in a bottle.” The two products produce similar results, but with two fundamental differences. First, Argireline is WAY less expensive. Second, unlike Botox which is injected directly into the deeper layers of the skin, Argireline is applied to the upper layers of the skin as an active ingredient in creams and serums to reduce the appearance of expression lines and wrinkles.

So how does it work? Essentially, Argireline reacts with the chemical compounds in your facial muscles to help them contract with less force, which means that you won’t pull as hard on your skin when you laugh or frown. This both diminishes the appearance of wrinkles in the short term and reduces their presence in the long run!

Wondering if Argireline is right for you? Consider the following if you’re thinking of adding an Argireline product to your regimen:

Argireline produces its most effective results in users with thinner skin. This is because of its topical application; it isn’t able to penetrate as deeply into the thicker surface, which will diminish the magnitude of its results. Our skin becomes thinner and more susceptible to wrinkles as we age, and the smaller our skin gets, the more receptive it is to Argireline treatment.

Most products come with an Argireline concentration of 20% or less. Higher levels can yield more powerful results, but also increase the risk of having an adverse reaction.

Since Argireline products are usually creams and serums, they almost always contain other active ingredients; remember to check the label before you begin to use a new product.

You should consult a dermatologist before beginning to use an Argireline product. The good news is that you’re probably already seeing a dermatologist about your cosmetic skin care concerns if you’re reading this article! You don’t need a prescription to use most Argireline products, but other medications or cosmetics that you use may not react well to it.

Ready to harness age-defying results to banish those wrinkles, but not prepared to drop a hefty sum on a cosmetic procedure? Consider trying one of these ten products, which all come consumer tested and approved!

Best Argireline Creams

Our Favorite
Face Whisperer Day Cream with Argireline, 1.7 oz. Anti Aging Moisturizer from Sublime Beauty to Relax Wrinkles & Hydrate (1 Jar)
Translucent and easy to apply.
Price not available
Highest Rated
Super moisturizing Hyaluronic Acid serum combined with the wrinkle reducing Argireline to eliminate pesky dark circles under your eyes.
Highest Quality
Anti aging Best Eye Cream : Eye Gel with Mediterranean Blue Algae Extract, Resistem, Chromocare, Renovage & Matrixylsynthe 6 - the best Formula 1.7 oz
Surprising results with dark circles and baggy skin around the eyes.
YEOUTH Neck Cream for Firming, Anti Aging Wrinkle Cream Moisturizer, Skin Tightening, Helps Double Chin, Turkey Neck Tightener, Repair Crepe Skin with Green Tea, Argireline, Vitamin C - 2oz (2oz)
Specially designed to firm wrinkled or loose skin on your neck.
Anti Aging Moisturizer with Peptides-Advanced Luxury Concentrated Argireline Cream for Face, Eyes, and Neck by Paloma Skin Therapy
Uses natural, responsibly sourced ingredients.
Price not available
Anti-aging Serum With Argireline (20%), Matrixyl 3000 (20%), Retinyl Acetate (Vitamin A) serum for facial skin. Best Argireline Serum/Cream For Eyes, Wrinkles with Hyaluronic Acid.
One of the most potent combinations of Argireline and Matrixyl 3000 on the market.
Price not available
MATRIXYL 3000 + ARGIRELINE Peptide + Vitamin C 4 oz Serum with Organic Hyaluronic Acid, Reduce Sun Spots, Wrinkles, Our Most Powerful Triple Combination ASTERWOOD NATURALS Bottle
Highly concentrated formula; a little bit goes a long way
Aprilis Anti-Aging Eye Cream, the Most Effective Eye Cream with Argireline for Instant Firming and Long-Term Reduction of Dark Circles, Puffiness, Wrinkles and Bags, 30 ml, 1 fl. oz
Diminishes the appearance of eye bags and dark circles.
Copper Peptide Serum With Swiss Apple Stem Cell and Argireline. Boosts Collagen Production. Ideal Result Working with Derma Roller.
Can also reduce appearance of acne scarring and stretch marks.
FaceLift by Ageless Beauty with Hyaluronic Acid | Acai Extract | Argireline | Matrixyl 3000 - Drastically Reduces Eye Bags, Wrinkles, Lines and Puffiness INSTANTLY! – Your BOTOX Alternative (10 Vials)
Produces instantaneous results.

Sublime Beauty Face Whisperer Day Cream

Sublime Beauty’s Face Whisperer Day Cream is packed with all kinds of natural botanical ingredients. Some, such as aloe vera, ginseng, and cucumber, you’re probably used to seeing in skin care products.

Others, like carrot, avocado, and the linden tree, may be less familiar to you. But each ingredient plays a crucial role in either moisturizing your skin, protecting it from free radicals, or cleansing away dirt and dead skin cells to leave you with a soft, radiant complexion. In addition to the botanical ingredients, Sublime Beauty as included another peptide compound called Trylagen that boosts your skin’s collagen production to improve its elasticity and firmness.

The strong presence of botanical infusions is probably one of the reasons that, in spite of its ability to produce results, this moisturizer is gentle enough to use twice a day if you’d like. Many customers prefer to use it as a night cream and are still able to see results even when using just once a day.

However, perhaps in part because of its gentle nature, you may need to use this cream consistently for 4-6 weeks to see the results you’re looking for with this product.

Pros and Cons

  • Translucent and easy to apply.
  • Gentle enough to use twice daily.
  • May require more than a month of consistent use to produce results.

Episilk Facial Relax Serum

vitasprings-episilk-facial-relax-serumEpisilk Facial Relax Serum is a powerful combination of Hyaluronic Acid and Argireline designed to hydrate, nourish and relax expression lines to lessen the appearance of wrinkles. Use it day or night for upkeep or when you feel your skin needs an extra boost, plus you can even mix this serum with cream for a fresh glow people are bound to notice.

To activate this serum, you need to put a little bit of water over your skin after you apply it to the face, that way it locks in the moisture. It’s recommended to wet your finger tips ever so slightly and rub in the water like a lotion.

Episilk is natural, and contains no harmful parabens, and is spa tested and fragrance free so there’s no unnecessary perfume aromas. This high quality formula is known to lessen the appearance of wrinkles, while simultaneously moisturizing the skin.

Pros and Cons

  • Great brand recognition
  • Highly concentrated formula; a little bit goes a long way
  • Made in small batches and can sell out quickly
  • Very potent, so be sure to use in small drops

First Botany Cosmeceuticals Intensive Cream

The First Botany Cosmeceutical Intensive Cream combines 5% Argireline with ingredients like 5% Leuphasyl® and Borage oil to create an anti-aging cocktail that will leave your skin looking and feeling younger than ever!

Borage oil has anti-inflammatory properties and can increase your skin’s production of the protective fuels that provide a buffer between your face and environmental toxins.

Leuphasyl® is a newer peptide developed by Lipotec that works in much the same way as Argireline. When used together in creams the two ingredients product compounded positive effects, nearly doubling the effectiveness of each ingredient!

The produce comes out of the bottle like a soft mousse that goes onto the skin effortlessly for a super light finish. Be careful when applying this product though; a little goes a long way, and you’ll lose that smooth finish if you use more than you need. However, even many users who did not love the finish of the product noted that they could see improvement within a week or two of consistent use.

Pros and Cons

  • Contains additional peptides to magnify positive anti-aging effects.
  • Surprising results with dark circles and baggy skin around the eyes.
  • May leave residue behind if you apply too much.

YOUTH Neck Cream

Lots of anti-aging products are focused on issues with your complexion, but that isn’t the only place where aging symptoms can sneak up on you.

Your hands and your neck are also common problem areas as a result of sun exposure and frequent movement. If you’re looking for a product to firm up and strengthen loose, thin, and sagging skin in your neck area then you should check out YEOUTH’s neck cream.

The Argireline in this product immediately gets down to business protecting your skin from further damage while other active ingredients begin to repair and restore your skin’s natural youthful qualities. Green tea contains a compound that can reactivate aging skin cells to encourage them to heal themselves, and delivers antioxidants to support them while they do it.

And Vitamin C infuses your skin with the moisture it needs to stay healthy and firm, which both helps to reduce the appearance of wrinkles and to prevent them from deepening in the future.

Users are amazed at what a difference this product makes, and some love it so much that they use it to correct deep lines on their face as well. The product feels thick when applied but won’t gunk up your pores and can be worn under makeup without affecting your flawless finish.

Pros and Cons

  • Specially designed to firm wrinkled or loose skin on your neck.
  • Smooth, easy application.
  • Can also be used on your face.
  • Fine lines may fill quickly, but firming loose skin may take weeks of consistent use

Paloma Skin Therapy Anti-Aging Moisturizer

The Paloma Skin Therapy Anti-Aging Moisturizer contains some anti-inflammatory and skin-restoring ingredients that work in tandem with the cream’s 8% (by volume) Argireline concentration to restore and refresh your skin with every use.

Coconut oil, for example, prevents excessive moisture loss by providing additional fatty acids that your skin can use to repair itself and to avoid extreme moisture loss. In fact, the anti-inflammatory and restoring ingredients in this moisturizer can even work to reduce the appearance of symptoms like under eye circles and bags.

Each formula is produced in small, controlled batches to ensure that each container is filled with preserved, fresh product. Additionally, each bottle incorporates an airless pump to ensure that the product continues to stay clean – uncontaminated by the oils from your fingers or contaminants in the air – until your bottle runs dry. And a little product goes a long way with each use, so one bottle could last for several months!

Pros and Cons

  • Uses natural, responsibly sourced ingredients.
  • Carefully batches to ensure freshness.
  • May cause a slight tingling sensation on application.

Acetyl Organics PREMIUM Anti-Aging Serum

The PREMIUM serum’s potent combination of 20% Argireline and 20% Matrixyl 3000 is the key to its ability to produce incredible results in a fraction of the time that many other products offer.

The benefits of Matrixyl 3000 (massive boost to collagen production and reverse UV damage) work to improve your skin quality over the long-term while Argireline provides the instant gratification of decreasing the visible appearance of wrinkles and fine lines.

The concentration of these ingredients is among the highest available without a prescription, and Acetyl Organics offers a 21-day money-back guarantee. That’s right – 21 days!

21 days may sound too good to be true, but users reviews to support the claim. You should keep in mind, however, that those immediate results are the result of high concentrations of the serum’s active ingredients. If you have sensitive skin or have never used products with these parts before, you may want to consider trying a lower-strength product first to introduce those ingredients to your skin and minimize the risk of having an adverse reaction.

Pros and Cons

  • One of the most potent combinations of Argireline and Matrixyl 3000 on the market.
  • Yields results in as little as three weeks
  • High concentration of active ingredients may be too harsh for more sensitive skin

Asterwood Naturals Anti-Aging Serum

After woods Naturals uses a blend of potent ingredients to deliver a high-impact anti-aging serum. In addition to Argireline, each bottle is also blended with Matrixyl 3000™, which boosts your skin’s natural collagen production so that it can firm and repair itself over time, and Vitamin C, which delivers antioxidants to keep your skin healthy and balanced.

Vitamin C also can minimize the appearance of your sun spots over time to restore a youthful, even complexion, attacking multiple symptoms of aging with each use.

An infusion of hyaluronic acid helps to maintain your skin’s natural moisture to decrease risks of having adverse drying reactions to the powerful ingredients. However this product is reliable, so you should consider testing for sensitivity on a small area of your skin before using regularly.

This serum is made in small batches to ensure its freshness and quality. On the one hand, this enables Asterwood Naturals to avoid adding unnatural preservatives to their formula. On the other, it does also mean that batches can sell out quickly, so your purchase may carry an additional lead time if you order when supply is running low.

Pros and Cons

  • 5 active anti-aging ingredients in every jar.
  • Brand has endorsements from celebs and other media sources.
  • Product may be too high for sensitive skin.
  • Made in small batches and can sell out quickly

Aprilis Anti-Aging Eye Cream

The area around your eyes is particularly vulnerable to signs of aging; the skin around your eyes is so thin that it can dry out quickly and is very susceptible to damage.

However, this vulnerability also means that the skin around your eyes is more sensitive and easily irritated than the other parts of your face.

The Aprilis Anti-Aging Eye Cream is specially formulated to be strong enough to deliver useful results but gentle enough to avoid irritation and redness.

Ingredients like sweet almond protein and red algae extract work in tandem with Argireline by boosting your skin’s natural collagen production to regain its elasticity and fill out expression lines and wrinkles.

The Argireline, of course, minimizes any further deepening of those expression lines. Gentle vinifera seed oil and Jojoba oil moisturize your skin to strengthen it and protect it from further damage. And natural anti-inflammatory ingredients even work to brighten the dark circles under your eyes, which can darken as your skin weakens with age. So no matter what your eye area was aging concerns are, Aprilis has an ingredient to deliver the results that you need!

Pros and Cons

  • Diminishes the appearance of eye bags and dark circles.
  • Can be applied before putting on makeup.
  • Small 1 ounce package size.

MYM Copper Peptide Serum

The MYM Copper Peptide Serum is a powerhouse product that addresses all kinds of anti-aging skin concerns, from wrinkles and stretches marks to acne scarring and hyperpigmentation.

The star ingredients in this serum (other than Argireline, of course) are copper-3-peptide and apple stem cells.

Copper-3-peptide stimulates the production of three different types of collagen so that your skin cells can rebuild themselves. This means that this serum can produce even skin texture, reverse sun damage and hyperpigmentation, and reduce the appearance of acne scarring.

The apple stem cells are a unique ingredient that can drastically reduce the appearance of wrinkles. On its own, this part can decrease the size of lines by as much as 15% after 15 days of twice daily use but, when working in combination with Argireline in MYM’s serum, can reduce them by 25% after only ten days!

If you want to boost your results, try using the MYM Copper Peptide Serum with a derma roller. Some users dislike the serum’s metallic scent, and others note that they experience a slight burning sensation when using, but if you’re not bothered by either of these potential issues then you could see a dramatic improvement in reversing your visible signs of aging.

Pros and Cons

  • Visible results in less than one month.
  • Can also reduce appearance of acne scarring and stretch marks.
  • Produces even more significant results when paired with a derma roller.
  • May cause a stinging sensation on application.
  • Some users dislike the scent.

Ageless Beauty Instant Face Lift

“Instantaneous results” might sound too good to be true, but many customers can attest that they did see results within minutes of applying the Ageless Beauty Instant Face Lift serum!

So how do they do it? The Instant Face Lift uses ingredients that, by this point in the article, you’re already familiar with, such as Argireline, hyaluronic acid, Matrixyl 3000. It also incorporates another peptide compound called SNAP-8 that plumps and tightens your skin to topically reduce the appearance of wrinkles, fine lines, and sagging skin. As the serum dries, it lifts and tightens your skin to leave your skin looking younger and firmer instantly!

A few cautions if you decide to try this product: the results are dramatic, but they are also temporary and typically only last about 8 hours. This is a great product to have in your arsenal for significant events like holiday parties and fundraisers, but may not be the best product if you want to create long-lasting results.

Also, you’ll have to wait to apply your makeup after using the serum and should avoid asking it on top of another cream or moisturizer. However, despite these cautions, the immediate satisfaction you’ll get with every use makes this product a must-have on this list.

Pros and Cons

  • Produces instantaneous results.
  • Specifically targets the eye area.
  • Cannot immediately apply makeup
  • Does not mix well with other moisturizers
  • Results are temporary (8 hours)

Final Thoughts

Before you drop a small fortune on an invasive cosmetic procedure to lift your aging skin and fill in unwanted wrinkles and fine lines, try using one of these Argireline products instead. You’ll still have to pay for a visit to your dermatologist to make sure that you’re using a product compatible with your skin type, needs, and other medications you regularly take, but you’d be paying for that either way!

Argireline products can lead to similar results at a fraction of the cost and without the risks of invasive medical procedures.

So what are you waiting for? Talk to your dermatologist to see if one of these products is right for you!